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On the following day, the patient experienced tenderness and swelling on the Moderna COVID-19 vaccine administration site and subsided after the paracetamol consumption.Īn emergency room evaluation found 160/85 mmHg blood pressure, 22 breaths per minute respiratory rate, 100 beats per minute pulse rate, no fever, and 97% oxygen saturation on room air. The patient had 2 doses of Sinovac vaccine on January 2021 and February 2021 and had 1 dose of Moderna COVID-19 vaccine on August 20th, 2021. The family denied a history of mental illness, smoking, alcohol, and illegal drug use.

She has never taken any antiepileptic medication and has never suffered recurrent seizures. The patient has uncontrolled hypertension and a history of uncomplicated febrile seizures at age one.

Behavioral changes, communication difficulties, social disengagement, and confusion were reported by the patient’s family 1 day before admission. Symptoms began 1 day before hospitalization. We report a case of encephalopathy in a patient following Moderna COVID-19 vaccine administration.Ī 39-year-old female was hospitalized at Bethesda Lempuyangwangi Hospital Yogyakarta Indonesia, with the chief complaints of confused state, dizziness, nausea, vomiting, and epigastric pain. Research on the side effects of the Moderna COVID-19 vaccine on the nervous system is still limited, including encephalopathy cases. Clinical manifestations of encephalopathy are cognitive dysfunction, behavioral change, disorientation, tremor, paralysis, and seizure. Įncephalopathy is a brain dysfunctional state associated with neurological and psychiatric disorders. Brain-fogging symptoms (9.95%), vertigo-like symptoms (3.47%), coordination disturbance (0.93%), paralysis (0.69%), and seizures (0.69%) were reported by 1116 individuals (0.23%). Vaccine adverse effects range from moderate to severe. The Moderna COVID-19 vaccine was 94.1% effective in preventing COVID-19 cases in the third phase clinical study.

Moderna is a COVID-19 vaccination used in Indonesia. Since January 2021, the government has been promoting the COVID-19 immunization campaign. ConclusionĮncephalopathy related to the Moderna COVID-19 vaccine should be acknowledged as an adverse effect of the Moderna COVID-19 vaccine.ĬOVID-19 instances are growing in Indonesia, making it one of the worldwide epicenters in July 2021. This study is the first case report of encephalopathy following the administration of the Moderna COVID-19 vaccine reported in Indonesia up to our knowledge. The patient was discharged on the seventh day and completely recovered 1 week later. She received ceftriaxone, citicoline, and methylprednisolone. An increase of neutrophil-to-lymphocyte ratio (16.9) and C-reactive protein level (31.75 mg/L) indicates ongoing inflammation. The patient had a history of febrile convulsion in childhood. We describe a 39-year-old female with uncontrolled hypertension who showed behavioral change, communication difficulty, social withdrawal, and a confused state within 7 days from getting her first dose of the Moderna vaccine. Based on some research, Moderna has possible side effects throughout the body, including neurological symptoms. Recently, the Moderna messenger ribonucleic acid (mRNA) vaccine is one of the COVID-19 vaccines used in Indonesia. Since January 2021, one of the government’s primary policies has been the COVID-19 immunization program. Due to a rising number of COVID-19 cases, the Indonesian government implemented public health programs to lower the rate.